Research

RESEARCH STUDIES
Over a decade of investment in science
Since 2010, we’ve set out to formulate the most comprehensive and effective Foundational Nutrition supplement.
Our driving belief: High-quality ingredients combined with healthy gut function could improve the body’s ability to absorb and actually use essential nutrients.


Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1.
01 — THE SHIME STUDY RESULTS
In a set of in vitro studies simulating the human gastrointestinal tract, AG1 was shown to support a healthy gut.*
4.4x
more minerals available for absorption vs. a multivitamin tablet‡

WHY THIS MATTERS
Adequate nutrient levels are needed to deliver their intended benefits. The more accessible a nutrient is to the digestive tract, the easier it is for absorption.*
3.7x
increase in beneficial bacteria vs. control‡

WHY THIS MATTERS
Healthy bacteria are digestive allies that help break down food and support functions of the gut required to aid bloating and metabolism.*
44%
increase in short-chain fatty acid production vs. control‡

WHY THIS MATTERS
SCFAs are the superheroes of the gut: providing energy to digestive cells, helping keep the gut lining healthy, and supporting the immune system.*
“We intentionally designed AG1 to deliver a diverse spectrum of essential daily nutrients with pre and probiotics to support the gut, in a powder form that’s easier for your body to digest than a tablet.”*
Dr. Ralph Esposito

02 — SINGLE-ARM STUDY RESULTS
In a single-arm study that assessed the self-perceived efficacy of AG1, participants reported feeling positive impacts on stress, digestion, and energy.*


WHY THIS MATTERS
Internal changes aren't always felt. By giving your body the routine nutrients it needs, you’re able to experience benefits that build each day.*
of participants felt more energy
noticed less gas & bloating
of participants felt more calm
noticed less cravings during the day
felt digestion improved
OUR TEAM & FINDINGS
Our research team
To contribute to the emerging body of research on foundational nutrition and to keep AG1 at the forefront of it, we rely on an in-house team of doctors, scientists, and researchers dedicated to bringing you the highest quality supplement.
Peer-reviewed research
In addition to sharing our results, we collaborate with other experts and researchers in the scientific community to publish research in peer-reviewed scientific journals, helping to lead the discourse on the complex and crucial role nutrition plays in overall health.
NUTRIENTS
Foundational Nutrition: Implications for Human Health
Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.
Read paperFRONTIERS
Nutrient synergy: definition, evidence, and future directions
Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.
Read paperNUTRACEUTICALS
The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®
Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.
Read paperAPPLIED BIOSCIENCE
AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract
While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements, which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.
Read paperCURRENT ISSUES IN MOLECULAR BIOLOGY
AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model
Considering previous experimental data on AG1 and the growing evidence that various phytochemicals can act as prebiotics, the primary objective of the current experiment was to detail the specific effects of AG1 on gut microbial community composition by observing changes in community structure and function.
Read paperOne scoop. Every morning. For life.
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Frequently Asked Questions
Rise is great for anyone who wants to ensure their nutritional needs are met on a daily basis. It fills in the gaps where your diet falls short and provides the support you need to combat life’s daily stressors. Whether you are looking to overcome nutrient deficiencies or are training hard or traveling frequently, Rise provides nutritional support when you need it most. Rise is suitable for adults of all ages and lifestyles, including athletes and those following specialty diets. Children, pregnant or nursing women should seek professional medical advice before taking this or any other dietary supplement.
Unlock your potential: Don't let nutrient gaps hold you back. Our multivitamin delivers the building blocks for a healthier, happier you.
Unlock your potential: Don't let nutrient gaps hold you back. Our multivitamin delivers the building blocks for a healthier, happier you.
Unlock your potential: Don't let nutrient gaps hold you back. Our multivitamin delivers the building blocks for a healthier, happier you.
Unlock your potential: Don't let nutrient gaps hold you back. Our multivitamin delivers the building blocks for a healthier, happier you.
Unlock your potential: Don't let nutrient gaps hold you back. Our multivitamin delivers the building blocks for a healthier, happier you.